![]() Tribulus terrestris is an herb people have used for centuries to treat ED by increasing a person’s libido.Ī 2021 study suggests that Tribulus terrestris, ginseng, and L-arginine are suitable supplements for improving ED, possibly due to their positive effect on nitric oxide synthesis, which could enhance blood flow in the body. There is no recent research investigating the benefits of pregnenolone on ED. Some people may use it as a supplement to increase testosterone levels. Pregnenolone is a steroid hormone that helps the body produce other hormones, such as testosterone and DHEA. However, doctors classify this hormone as a performance-enhancing drug, which is why professional athletes are not eligible to take ExtenZe.M Pregnenolone A 2020 review notes that DHEA supplementation can significantly increase testosterone levels.ĭHEA is known to improve mood, sexual function, and cognitive ability. Dehydroepiandrosterone (DHEA)ĭHEA is a steroid hormone that is a precursor to both male and female sex hormones. More research from 2018 found that low folic acid may be a risk factor for ED, while in another study, folic acid supplementation could help improve erectile function in people with ED. A 2018 study found that weight training coupled with zinc supplementation improved testosterone levels. A zinc deficiency may also relate to hypogonadism, where the testes have problems producing the sex hormone testosterone, sperm, or both. Zinc is a necessary mineral for sperm formation - it works with folic acid to form DNA in sperm. Plus, the benefits noted in the 2017 study may be attributable to sildenafil, a well-known treatment for ED. However, both of these were rat studies and may not be applicable to humans. One older 2017 study suggests that icariin and daily sildenafil could treat neurogenic ED, while another study indicates that icariin may help treat diabetes-associated ED. Its active ingredient, icariin, is a PDE5 inhibitor, which causes arteries in the penis to relax, leading to increased blood flow to the area. Horny goat weedĪlso known as yinyanghuo or epimedium, horny goat weed is a herbal medicine popular in China as a treatment for ED. Yohimbe also promotes the release of nitric oxide that dilates blood vessels, allowing more blood into the penis. It works by blocking alpha-2 adrenergic receptors that inhibit erections. A 2018 study notes that yohimbine and ginseng were effective treatments for ED. YohimbeĪlso known as yohimbine, Yohimbe extract is an herbal supplement from the Pausinystalia johimbe tree that practitioners commonly use in West African medicine for ED. ![]() However, data from a 2018 literature review shows that there is no significant data on the bioavailability of GABA in supplement form, meaning it may not reach the brain or act on the cells it is meant to. For example, an older 2017 study suggests that a 75% GABA and 25% sildenafil mixture may be the most effective combination of these ingredients to help treat ED symptoms. GABA is a neurotransmitter that people may use for ED due to its vasodilatory properties. A similar study reports a similar effect when combining L-arginine with sildenafil, the active ingredient in Viagra. Evidence suggests it may work in combination with other ED ingredients.Ī 2021 study notes that combining phosphodiesterase type 5 (PDE5) inhibitors and L-arginine improved sexual function and testosterone levels more than monotherapy. L-arginine is an amino acid that may help develop erections easier and maintain them longer. Some of the active ingredients include: L-arginine The company has a variety of products with different ingredients. ExtenZe is a proprietary herbal blend containing several active ingredients that may help treat ED.
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